HYPOTHESES
- The autonomic nervous system and metabolic disorders are linked in the development of CVCs of diabetes
- CVCs can be prevented, minimized or reversed through targeted lifestyle and pharmacologic interventions
- Optimal interventions and technologies can be delivered at the point of care to ensure knowledge exchange
OBJECTIVES
- Determine and implement powerful designs to quantify the array of neural, cardiac, vascular and metabolic markers of CVCs along the continuum of pathology from early metabolic disturbances through to diabetes. We will emphasize novel end points including abnormalities in adipocytokine ratios, cardiovascular tissue structure and function, sympathetic neurophysiology, neurally-mediated cardodynamic control, insulin tolerance, endothelial function
- Establish a continuum of risk for CVCs from pre-diabetic children, youth, middle aged and older adults including models of obesity, sedentary lifestyle, metabolic syndrome and insulin resistance
- Quantify the impact, and mechanistic basis of, optimized prescriptive exercise countermeasures with and without pharmacologic interventions on the development of CVCs of diabetic and at-risk individuals at the point of care
- Development and establish new technologies and delivery models to support novel interventions at the point of care
OUTCOME
- This proposal will provide an innovative and potent catalyst for scientists, clinicians, and community partners to explore the causes and early indicators of CVCs of diabetes from tthe unique perspective of patient-centred knowledge exchange that will provide evidence for, and tolls to deliver, prevention and reversal of these leading sources of death and disability among Canadians
ARTEMIS GRANT
